Sr. Director, Translational Science
Company: Tarsus Pharmaceuticals
Location: Irvine
Posted on: May 8, 2024
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Job Description:
About the RoleThe Sr. Director of Translational Science, Eye
Care will be a leader in helping to develop and build the eye care
pipeline at Tarsus. They will be responsible for bringing the
biology/pharmacology expertise in defining the translational
strategy for pipeline projects. The role bridges the discovery and
clinical development organization and aims at supporting projects
at the interface between discovery and early clinical
development.Let's talk about some of the key responsibilities of
the role:Collaborate with key experts across the company including
Clinical Development and Business Development (BD) to drive
translational strategy from preclinical development through
candidate selection and contribute to translational strategies in
early clinical development through early Proof of Concept.Establish
stage-appropriate project translational strategy for a
differentiated asset to address unmet patient need with key "Go/No
Go" decision points.Design non-clinical experiments to support
biomarker strategy, combination strategy as well as overall
MOA-related translational questions.Contribute to the analysis and
interpretation of clinical biomarker results, evaluation of
translational hypothesis based on clinical data, and data-driven
generation of new hypotheses.MAIN RESPONSIBILITIESIn vivo
translational biology/pharmacology:Build and develop deep expertise
in disease areas within ophthalmology, which are prioritized by the
company. Identify possible mechanisms, disease models, preclinical
POC approaches.Based on the scientific questions raised in the
project, and in accordance with the translational and biomarker
plan of the project, propose study designs and sequences (based on
actual knowledge and literature review).Generate clear, testable
translational hypothesis to address unmet needs (mechanism of
action, pharmacodynamics, patient selection).Identify most relevant
models, liaise with the best CRO and interact with academic experts
to evaluate potential assets.Translational sciences strategy:In
collaboration with clinical development, define translational
strategy on projects with the objective to guide clinical
development: indication identification, patient stratification
strategy, combination potential, optimization of dose selection,
overall biomarker strategy, etc.In partnership with clinical
development, build the differentiation strategy for the therapeutic
as well as defining the clinical and mechanism of action hypothesis
and disease indication selection for early clinical
development.Contribute to hypothesis-driven study design,
execution, and data analysis, including identification of most
relevant preclinical and ex vivo models.Identify key scientific
questions in the projects and builds translation sciences plan
according to their priority level.Due diligenceBring scientific
expertise to due diligence in collaboration with BD team, identify
main risks and mitigation plan in their area of expertise.Build
open relationships with peers and external partners to ensure best
decision making.Clearly identify risks and mitigation plans.
Ensures team contribution to clinical development plan.Factors for
Success:Minimum Requirements/Qualifications:MD (Ophthalmology) with
a minimum 5+ years experience in the pharmaceutical industry or in
a venture capital/entrepreneurial environmentPhD degree in
pharmacology, cell biology or related field with 10+ years'
experience and a minimum of 6+ years in the pharmaceutical or
industry setting.Proven project team leadership or a translational
team member role in an industry setting for assets progressing
through IND-enabling studies and/or Phase I/II trials.Superior
knowledge and solid understanding of emerging research, mechanisms
of action and disease models in anterior and posterior segment eye
care diseases, preclinically and clinically.Knowledge of the
clinical landscape in ophthalmology indications with good
understanding of novel agents and impact to this
landscape.Excellent oral and written communication skills,
including writing, reviewing, and editing scientific
documents.Superior interpersonal skills, diplomacy, and
positive-influencing abilities.Leadership ability to drive
decision-making within a multi-disciplinary, matrix teams.Ability
to demonstrate effective leadership behaviors to ensure effective
outcomes, including business agility as well as a curious,
open-minded, and solution focused mindset.Effective project
management skills.Independent management of workload and
expectations.Scientifically independent.Enterprise and
entrepreneurial mindset.Preferred experience/background:Experience
in clinical sciences, including contribution to clinical trials or
to observational clinical studies in an academic or industry
setting.Track record of success and measurable contribution in
moving ophthalmology therapeutic programs forward through
preclinical and/or clinical development in an academic or industry
setting.Experience in research and/or development of anterior
and/or posterior eye care segment therapies.A Few Other Details
Worth Mentioning:The position will be based in our beautiful Irvine
office, complete with a courtyard, snacks, drinks, and occasional
catered meals. We provide a hybrid work environment. Remote work is
an option.We are passionate about our culture! Our Tarsans live our
values of commitment to patients, empowerment to champion
innovation, and teamwork to amplify impact!This position reports
directly to our Chief Operating OfficerSome travel may be required
- up to 20%At Tarsus, we understand the importance of attracting
and retaining top talent. The expected base pay range for this
position is $240,000 - $336,000 plus bonus, stock equity, and
comprehensive benefits. The base pay range reflects the target
range for this position, but individual pay will be determined by
additional factors such as job-related skills, experience and
relevant education or training. Our benefits include health, dental
and vision insurance benefits to ensure your well-being. We believe
in work-life balance and offer generous paid time off, including
vacation, holidays, and personal days. For more details regarding
Tarsus benefits, please visit: . -#LI-Hybrid #LI-RemoteTarsus
Pharmaceuticals, Inc. is an Equal Opportunity Employer. All
qualified applicants will receive consideration for employment
without regard to race, color, religion, sex including sexual
orientation and gender identity, national origin, disability,
protected Veteran Status, or any other characteristic protected by
applicable federal, state, or local law.
Keywords: Tarsus Pharmaceuticals, Corona , Sr. Director, Translational Science, Executive , Irvine, California
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